Sun damaged skin is not with estrogen treatment improve.

Treatment for skin with estrogen can stimulate collagen production improves the appearance of the skin in areas normally not the sun exposed according to new research from the University of Michigan Health System. But in Sun damaged skin, the same treatment not collagen production, the study found. But in Sun damaged skin, the same treatment not collagen production, the study found. The results highlight, therefore it is so difficult, the effects of sun damage on the skin, reverse says investigators lead author Laure Rittie, Ph.d, research in the U-M Department of Dermatology. "Frankly, we were very surprised to learn, that stimulating collagen production of topical estrogen treatment is limited to the skin sunlight suspended not chronic. These results suggest that sunlight changed skin ability to respond to current estrogen and show how difficult it is to repair skin Photoaged, "says Rittie." The study will be published in the new issue of the archives of Dermatology. Seventy seniors 40 post-menopausal women and 30 took men in the study. Researchers analyzed biopsies of of the patient's skin hips, and forearm or taken face, before the treatment began and ended after two weeks later. Study participants had all Photoaged skin-that is, Sun damaged skin, dry, coarse wrinkles and uneven pigmentation appears. Participants were called topically treated estradiol with estrogen medication. They were given doses of 0.01%, 0.1%, 1% or 2.5% or a vehicle include no estradiol. Estradiol was more than tripled, on average, compared to the inactive drug found to increase collagen levels in women's hip skin. These included p4ha1 I and III to mRNA levels. In men, the collagen levels increased by a factor of approximately 1.7 on average. The improvements were later, when the doses of estradiol were higher. In contrast to collagen levels in Photoaged skin on the forearm and face with treatment, no matter the dosage of estradiol not significantly improved. Authors: In addition to Rittie, were: Sewon Kang, m.d, Professor of Dermatology; John j. Duncan, Voorhees, MD, Ella Poth distinguished professor and Chair, Department of Dermatology; and Gary j. Fisher, Ph.d., Harry Helfman Professor of molecular Dermatology. Funding: A grant from Pfizer Inc. supports the research part. Disclosure: Voorhees served as a consultant for Pfizer Inc. and receive advice. Reference: Archives of Dermatology, vol.. 144, No. 9, September 2008.

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