The results of the study show that Sulforaphane, a chemical in the broccoli, switches to a set of antioxidant genes and enzymes in specific immune cells, which then fight the damaging effects of molecules that can damage the cells and cause disease known as free radicals. Eat your broccoli! That's the advice of UCLA researchers who have found that a chemical in the broccoli and other cruciferous can hold a key to restore the body the immunity which decreases vegetables when we get older. Published this week online edition of the journal of Allergy and Clinical Immunology, the results of the study show that Sulforaphane, turns a chemical in the broccoli to a set of antioxidant genes and enzymes in specific immune cells, which then fight the damaging effects of molecules that can damage the cells and cause disease known as free radicals. Free radicals are by-products of normal body processes such as such as metabolic converting food into energy, and can enter the body through small particles in polluted air. A charged form of oxygen, can cause these molecules oxidative tissue damage, leading disease - for example, the triggering of the inflammation process, that causes clogged arteries. Oxidative damage to body tissues and organs is one of the main causes of aging thought. "The secrets of aging have always fascinated man", said Dr. Andre nel, the study principal investigator and head of nanomedicine at the David Geffen School of medicine at UCLA. "While we since some time have known the free radicals are aging, important, most of the recent attention mechanisms focuses the free radicals, rather than the means used by the body to produce your production to suppress addressing on." A dynamic balance exists in the body between the mechanisms to help lead to increased free radical production and these antioxidant passes that fight free radicals. "Our study contributes to the growing understanding of the meaning of this antioxidant defence pathways that the body will fight used to free radicals," said nel, a practicing clinical Allergist and immunologist at the Geffen School. "We shows insight into these processes ways in which may be able to mitigate the effects of aging." The delicate balance between pro-oxidant and antioxidant forces in the body could determine the result of many disease processes, with aging, including cardiovascular diseases, degenerative joint diseases and diabetes, and the decline in effectiveness of the immune system ability to protect against infectious agents are linked. "When we get older the ability of the immune system to fight the disease and infections and protection against cancer is down as a result of the effects of oxygen radicals on the immune system," nel said. UCLA study, I can play an important role to revive the ability at the age of tissues, your antioxidant defense reverse much of the negative effects of free radicals on the immune system. However, until this recent study was the extent to which, the antioxidant defence the aging process of the immune system may have not correctly understood. "Our defense against oxidative stress damage may determine what speed we age as it will manifest and how to use these processes to bother", nel said. "Especially our study shows that a chemical in broccoli is available able, defence means stimulate a wide variety of antioxidants and can immune function might interfere with the age-related decline." The UCLA team not only found that the direct management of Sulforaphane in broccoli, falling of the cellular immune function in old mice vice versa but you similar results, witness if they old mice, took individual immune cells treated these cells with the chemical outside the body and was then the treated cells again in a recipient animal. In particular the scientists discovered that dendritic cells, the infectious agents and foreign substances in the immune system introduce particularly effective in restoring the function of the immune system in aged animals, when you have been treated with Sulforaphane. "We found that treating older mice with Sulforaphane of immune response increased level of younger mice," said Hyon David Kim, first author and scientist at the Geffen School. To examine how the chemical in broccoli of immune system increase response, the UCLA Group confirmed that Sulforaphane interacts with a protein called Nrf2 which as a master regulator of the body is antioxidant overall response rate is able of the changeover on hundreds of antioxidant and rejuvenating genes and enzymes. Nel said that the chemical industry to enable of this gene regulation pathway a platform for drug discovery and vaccine could be development to increase of decrease in function of the immune system in the elderly. "This is to increase a radical new way of thinking in elderly immune function, may protect against virus infection and cancer," said nel. "We can a new mechanism to vaccine answers boost using a nutrient effects of chemical oxidant stress pathways in the immune system have revealed." Kim said, that it while a decline in the Nrf2 activity with aging, this way for chemicals such as Sulforaphane accessible which remains some of the ravages of aging to restore through a greater antioxidant ways are capable. The next step is to see how this would translate results to humans more study. "Dietary antioxidants have been shown, to important effects on immune function, and with further study, we can add broccoli and other cruciferous vegetables to this list," nel said. For now, nel proposes including these vegetables as part of a healthy diet. Nel said that these results offer a window in the immune system as ages. "We can find that combating free radicals is only part of the answer." It can be a more diverse process and interaction between pro- and antioxidants prove forces ", he said." The study was on Aging, the UCLA Claude D. Pepper by the National Institute older adults independence Center and the National Institute of Allergy and infectious diseases funded. Other authors of the study included Berenice Barajas and Dr. Meiying Wang.
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