Scientists from the University of Florida's Institute on aging have found that a little less food to eat and the exercise reduce a little more of a life or even aging-related cell and organ damage in rats a lifelong habit reverse, trimming can only few calories from the daily diet can do more than the waist ? a new study shows slim it can help to reduce the effects of aging. Scientists from the University of Florida's Institute on aging have can reverse found that a little less food to eat and exercise a little more reduce over a lifetime or even aging-related cell and organ damage in rats. The discovery of antioxidants and redox signaling, described this month in the journal builds on recent research in animals and humans, a drastic reduction of 20 to 40 percent calories shown aging slowed damage. Displaying the UF results small cuts in calories could have a major impact on health and shed light on the molecular process responsible for the phenomenon that is poorly understood so far. "This finding suggests that even slight moderation in intake of calories and a moderate movement program shows an important organ such as liver, significant signs of a dysfunction in the aging process is" the senior author said Christiaan Leeuwenburgh, Ph.d, Associate Professor of aging and geriatric research at the UF College of medicine and the paper. UF researchers found that feeding rats their average lifetime extends activity only 8 percent of fewer calories per day and moderate increase of animals and significantly raised the negative impact of cellular ageing on liver function and general health. A 8% reduction is the equivalent of a few hundred calories in an average human diet and moderate exercise is synonymous with a short walk. To reveal the functioning of the body chemical climate when relating to aging damage happens, UF of researchers levels of biomarkers - chemicals and molecules tracks available in the liver - group of rats. The liver is a vital institution for maintaining good health during the aging purifies the blood and helps regulate the body's immune system. The researchers plan same biomarkers in a study of rats heart to assess muscle and brains. The research team was surprised to find one which biomarkers, RNA, which is important is faster ageing for encoding DNA and protein synthesis, as more often studying DNA damaged. RNA damage, therefore excellent early signal at the start of aging could be, researchers say. "Because it more sensitive can be useful to oxidative stress, RNA as an early marker of oxidative damage and even aging," said Arnold y SEO, doctoral student in UF's Institute on aging. Written report with Tim Hofer, Ph.d, an Institute on aging link research SEO. "To avoid disease, we can increase our defence and search aging biomarkers and test interventions," said Hofer. "It is better to protect, what it is to rely on the quality of life rather than invasive operations." Group of animals ate how much food as you wanted in the study who to follow, the rats about your life and exercise, another group of animals easily exercised and something ate less than you would have if allowed, your fill been fed. Samples from these groups were compared to samples from young rat liver. The old sedentary rats that ate, full until you were increased by oxidierenden levels of harmful and inflammatory molecules in the liver damage with cell ageing were connected. In the meantime, aging rats that exercised and a reduced-calorie diet consumed had the reverse result - showed that a decrease these molecules in the liver. Leeuwenburgh said the findings support the theory that the cell death and aging-related organ damage by unstable molecules known as free radicals and causing cellular oxidation and inflammation. "In a calorie-reduced environment, decrease the inflammatory response and to prevent that cell death", said Leeuwenburgh. John O. Holloszy, Professor of medicine in the Division of Geriatrics and nutritional science at the Washington University School of medicine in St. Louis, said the study of great importance, because it shows a mild degree of caloric restriction - just enough to prevent weight gain with advancing age - can have beneficial effects against ageing. From a scientific perspective, he added, it is important to learn that RNA is one very good marker of the aging damage. "I never before had thought about RNA", said Holloszy. "Research has examined always DNA." "Because RNA is the template for the information on the genes on the DNA, RNA damage is a big problem because it leads mutations in transcription of proteins."
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